Jennifer A. Doll, Ph.D.
Enderis Hall, Room 429
Phone: (414) 229-5962
Fax: (414) 229-2619
- Ph.D., Molecular Genetics, Washington University, St. Louis, MO, 1997
Thesis title: “Molecular Genetic Studies of Prostate Cancer.” Mentor: Helen Donis-Keller, Ph.D.
- M.S., Biology, Loyola University, 1994
Thesis title: “A Physical Map of the Short Arm / Centromere Region of Human Chromosome 21.” Mentor: Jeffrey Doering, Ph.D.
- B.S., Biology, Rockhurst College, Kansas City, MO, 1990
- Cancer Biology
- Prostate Cancer
- Obesity and Dietary Fats in Prostate Cancer
Dr. Doll’s research is centered around prostate cancer (PCa) and the effects of obesity and a high fat diet on disease progression. Her work has evolved around the study of two angiogenesis inhibitors, pigment epithelium-derived factor (PEDF) and thrombospondin-1 (TSP-1). Angiogenesis, the growth of new blood vessels from the existing vasculature, is a necessary step for the progressive growth of tumors. Both TSP-1 and PEDF are expressed in the normal prostate but, in PCa patient tissues, expression is decreased or absent, thus suggesting a role in disease progression. Interestingly, several lines of data suggest that both of these proteins also function in regulating lipid metabolism. This is of particular interest in PCa as a high fat diet and obesity have been consistently associated with more aggressive disease and increased risk of death from PCa. However, the mechanisms of this association remain unclear. Dr. Doll’s research is focused on elucidating these functional mechanism(s) and specifically delineating the role of TSP-1 and PEDF in regulating lipid metabolism in the prostate. Understanding the molecular pathways stimulated in PCa cells by obesity and dietary fats will allow the rational design of novel therapies for treatment as well as new strategies for chemoprevention.
Homan, E. P., Rauch, F., Grafe, I., Lietman, C., Doll, J. A., Dawson, B., Bertin, T., Napierala, D., Morello, R., Gibbs, R., White, L., Miki, R., Cohn, D. H., Crawford, S., Travers, R., Glorieux, F. H., & Lee, B. (2011). Mutations in SERPINF1 cause Osteogenesis imperfecta Type VI. J Bone Miner Res, 26(12), 2798-803. PMID: 21826736
Fitchev, P. P., Wcislak, S. M., Lee, C., Bergh, A., Brendler, C. B., Stellmach, V. M., Crawford, S. E., Mavroudis, C. D., Cornwell, M. L., & Doll, J. A. (2010). Thrombospondin-1 Regulates the Normal Prostate In Vivo Through Angiogenesis and TGF-Activation. Lab. Invest, 90, 1078-90. PMID: 20458281
Halin, S., Rudolfsson, S. H., Doll, J. A., Crawford, S. E., Wikstrom, P., & Bergh, A. (2010). Pigment Epithelium-Derived Factor a Prostate Tumor Suppressor with Diverse Biological Effects in the Microenvironment. Neoplasia, 12(4), 336-45. PMID: 20360944
Yu, N., Kozlowski, J. M., Park, II, Chen, L., Zhang, Q., Xu, D., Doll, J. A., Crawford, S. E., Brendler, C. B., & Lee, C. (2010). Over-expression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor. Urology, 76, 1519. e8-1519.e13. PMID: 21030067
Chung, C., Shugrue, C., Nagar, A., Doll, J. A., Cornwell, M., Gattu, A., Kolodecik, T., Pandol, S., Gorelick, F. (2009). Ethanol exposure depletes hepatic pigment epithelium-derived factor (PEDF), a novel lipid regulator in the liver. Gastroenterology, 136(1), 331-40. PMID: 18996124
Plunkett, B. A., Fitchev, P., Doll, J. A., Gerber, S. E., Cornwell, M., Greenstein, E. P., & Crawford, S. E. (2008). Decreased expression of pigment epithelium derived factor (PEDF), an inhibitor of angiogenesis, in placentas of unexplained stillbirths. Reprod Biology, 8(2), 107-20. PMID: 18677399
Signaevsky, M., Hobbs, J., Doll, J., Liu, N., & Soff, G. A. (2008). Role of alternatively spliced tissue factor in pancreatic cancer growth and angiogenesis. Semin Thromb Hemost., 34(2), 161-9. PMID: 18645921
Chung, C., Doll, J. A., Gattu, A., Shugrue, C., Cornwell, C., Fitchev, P., & Crawford, S. E. (2008). PEDF regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL). J. Hepatol., 48(3), 471-8. PMID: 18191271
Chung, C., Doll, J. A., Stellmach, V. M., Gonzales, J., Surapureddi, S., Cornwell, M., Reddy, J. K., & Crawford, S. E. (2008). Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha. Adv Exp Med Biol., 617, 591-7. PMID: 18497086
Hobbs, J. E., Zakarija, A., Cundiff, D. L., Doll, J. A., Hymen, E., Cornwell, M., Crawford, S. E., & Soff, G. A. (2007). Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. Thrombosis Res., 120 Suppl 2:S13-21. PMID: 18023707
Published Book Chapters
Doll, J. A., Hobbs, J. E., & Soff, G. A. (2007). Role of Apoptosis in Anti-angiogenic Cancer Therapies. In Apoptosis and Senescence in Cancer Chemotherapy and Radiotherapy. Humana Press, Inc., Totowa, NJ.
- 2010: Invited talk at the Prostate Cancer Foundation’s Annual Retreat (Washingtion, D.C., September 15-16, 2010).
- 2009: Invitation to the NCI Translational Science Meeting (poster presentation with oral summary), Vienna, VA, November 2009.
- 2007: Invitation to the DOD prostate cancer IMPaCT Meeting (poster presentation), Atlanta, GA, September, 2007.
- 2001: Travel Grant Award, AACR: AACR’s “New Discoveries in Prostate Cancer Etiology and Treatment” meeting, Naples, FL, December, 2001.
- 1998: Travel Grant Award, AACR: AACR’s “New Research Approaches in the Prevention and Cure of Prostate Cancer” meeting, Indian Wells, CA, December, 1998.
- 1998: Travel Grant Award, NIH: Biology of Prostate Growth Meeting, Bethesda, MD, March, 1998.
- 1994: Travel Grant Award, AACR: AACR’s “Basic and Clinical Aspects of Prostate Cancer” meeting, Palm Springs, CA, December, 1994.
- 1992: Graduate Research Fellowship, Loyola University
- 1990: Barbara Wynne Outstanding Biology Student Award, Rockhurst College.